Abstract:

The prophylaxis can prevent disability  in hemophilia. The ideal regimen  has not been determined yet. Individualized prophylaxis in children with hemophilia will be the direction of future development. Designing a prophylactic project for severe hemophilia must take into account each patient’s bleeding phenotype，pharmacokinetic profiles and joint assessment，even thrombin time. Optimal outcome，such as reducing hemorrhage，preventing joint damage，and improving quality of life， can be achieved through an individualized prophylaxis.

Key words: hemophilia, individualized, prophylaxis

摘要：

预防治疗是降低血友病致残率的关键，但预防治疗剂量方法依经济条件、凝血因子在体内代谢的不同而各地有所差异， 而且在临床， 同样的凝血因子浓度，患儿出血倾向却并不完全相同。因此，个体化预防治疗将是未来的方向。应分别从基于药代动力学的预防治疗方案、基于临床出血症状的预防治疗方案、基于关节评估的预防治疗方案，以及基于凝血酶时间的预防治疗方案等方面，对血友病进行个体化预防治疗。

关键词: 血友病, 个体化, 预防治疗