中国实用儿科杂志

中国实用儿科杂志 ›› 2024, Vol. 39 ›› Issue (11): 815-819.DOI: 10.19538/j.ek2024110603

• 专题笔谈 • 上一篇    下一篇

特纳综合征生育力评估及生育力保护的研究进展

  

  1. 郑州大学附属儿童医院 河南省儿童医院内分泌遗传代谢科，河南  郑州  450018
  • 出版日期:2024-11-06 发布日期:2024-12-24
  • 通讯作者: 卫海燕，电子信箱：haiyanwei2009@163.com
  • 基金资助:
    河南省科学技术厅项目（232102310088）；郑州市科技惠民计划项目（2022KJHM005）

Research advances in fertility assessment and fertility protection inTurner syndrome

  1. Zhengzhou University Affiliated Children’s Hospital;  Endocrinology，Genetics and Metabolism Department，Henan Children’s Hospital，Zhengzhou  450018，China
  • Online:2024-11-06 Published:2024-12-24

摘要： 女性生育力即卵巢储备功能，生育力保护是指对可能引起女性生育力受损的因素采取早期筛查、治疗及特殊的生育力保存措施，以达到产生遗传学后代的能力。早发性卵巢发育不全是特纳综合征（Turner syndrome）的主要临床特征，约98%的患儿卵巢储备功能在成年前出现衰竭、生育力丧失，仅有2%的患儿成年后能够自然受孕。在儿童期及青春期早期，部分患儿的卵巢储备功能尚存在。该文重点阐述如何在早期对特纳综合征患儿进行卵巢功能评估，并在合适的时机启动卵巢功能保护措施。

关键词: 特纳综合征, 先天性卵巢发育不全, 生育力评估, 生育力保护

Abstract: Female fertility refers to ovarian reserve function. Fertility protection refers to the early screening，treatment and special fertility preservation measures for factors that may cause impaired female fertility，so as to achieve the ability to produce genetic offspring.Premature ovarian hypoplasia is the main clinical feature of Turner syndrome，and about 98% of patients have ovarian reserve failure and fertility loss before adulthood，so only about 2% of patients are able to conceive naturally in adulthood. In childhood and early adolescence，ovarian reserve is still present in some children. This article focuses on how to evaluate the ovarian function of children with Turner syndrome at an early stage，and how to start the protective measures for ovarian function at the right time.

Key words: Turner syndrome, congenital ovarian hypoplasia, fertility assessment, fertility protection