中国实用儿科杂志

中国实用儿科杂志 ›› 2024, Vol. 39 ›› Issue (5): 321-324.DOI: 10.19538/j.ek2024050601

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重视新生儿坏死性小肠结肠炎临床与基础研究

  

  1. 上海市儿童医院，上海  200062
  • 出版日期:2024-05-06 发布日期:2024-05-09
  • 通讯作者: 吕志宝，电子信箱：lvzhibao@sohu.com
  • 基金资助:
    国家自然科学基金项目（82171696，82371711，82001591）

Attention to necrotizing enterocolitis in children

  1. Shanghai Children’s Hospital，Shanghai  200062，China
  • Online:2024-05-06 Published:2024-05-09

摘要： 新生儿坏死性小肠结肠炎（necrotizing enterocolitis，NEC）是导致新生儿尤其是早产儿和低出生体重儿死亡的重要病因。如何早期识别并精准判断病情严重程度，如何把握NEC患儿的手术时机，以及探索有效的干预措施成为当前临床研究的热点。研究早产儿肠道黏膜屏障受损和修复、免疫应答异常的具体机制对于明确NEC的发病机制、探索新的干预策略以及改善患儿的预后，具有重要的理论意义和临床价值。

关键词: 早期诊断, 手术时机, 肠道黏膜屏障, 免疫应答

Abstract: Necrotizing enterocolitis （NEC） remains one of the leading causes of death of the newborn，especially in the preterm and low birth weight neonates. How to identify and accurately determine the severity of the disease early，how to grasp the surgical opportunity of children with NEC，and explore effective intervention measures have become the hot topic of current clinical research. New discoveries in the basic research including intestinal mucosal barrier and inappropriate inflammatory response. Current work will shed light on explaining the pathogenesis of NEC，potential therapeutic methods，and ultimately improve outcomes in NEC.

Key words: early diagnosis, surgical timing, intestinal mucosal barrier, immunological response