中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (10): 754-758.DOI: 10.19538/j.ek2023100608

• 专题笔谈 • 上一篇    下一篇

核苷酸及其在线粒体病治疗中的应用

  

  1. 1.上海交通大学医学院附属新华医院，上海  200092；2.北京大学第一医院儿科，北京  100034
  • 出版日期:2023-10-06 发布日期:2023-09-27
  • 通讯作者: 杨艳玲，电子信箱：organic.acid@126.com
  • 基金资助:
    国家重点研发计划（2021YFC2700903）

Nucleotides and their application in the treatment of mitochondrial disorders

  1. *Department of Pharmacy，Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai  200092，China
  • Online:2023-10-06 Published:2023-09-27

摘要： 核苷酸是一组重要的营养素，参与人体多种生理代谢反应，包括能量代谢、细胞表达及信号传导等。核苷酸作为ATP生成的重要载体之一，为线粒体提供更多的能量载体和原料，对于大多数因三磷酸腺苷（ATP）合成缺陷导致的线粒体病治疗可能具有优秀的潜力，文章就核苷酸的生理作用进行整理综述，以期进一步探究核苷酸的药理和临床应用价值。

关键词: 核苷酸, 营养素, 能量代谢障碍, 线粒体病

Abstract: Nucleotides，a group of important nutrients，involve in many reactions of human physiological metabolism，including energy metabolism，cell expression and signal transduction. As one of the important carriers of ATP production，nucleotides may provide more energy carriers and raw materials for mitochondria. Nucleotides may have excellent therapeutic potential in most mitochondrial diseases secondary to ATP synthesis defects. The review focuses on the physiological effects of nucleotides in order to further explore the pharmacological and clinical value of nucleotides.

Key words: nucleotides, nutrients, energy metabolic disorder, mitochondrial disorders