中国实用儿科杂志

中国实用儿科杂志

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同基因外周血干细胞移植治疗儿童血液病4例报告

周翾，吴敏媛，朱光华   

  1. 首都医科大学附属北京儿童医院血液病中心，北京100045
  • 收稿日期:2006-03-10 修回日期:2006-07-22 出版日期:2006-10-06 发布日期:2006-10-06

The outcome of syngeneic peripheral stem cell transplantation in four pediatric patients with leukemia and aplastic anemia.

Zhou Xuan,Wu Minyuan,Zhu Guanghua.   

  1. Hematology Center,Beijing Children's Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China
  • Received:2006-03-10 Revised:2006-07-22 Online:2006-10-06 Published:2006-10-06

摘要： 目的观察同基因外周血造血干细胞移植治疗儿童再生障碍性贫血、白血病的植入情况及疗效。 方法北京儿童医院于200408—200412，对4例分别患有慢性粒细胞性白血病(慢性期)、急性非淋巴细胞白血病(M2)、急性再生障碍性贫血、急性淋巴细胞白血病(ph1+)的患儿进行正规方案治疗，3例白血病患儿获得首次缓解，4例患儿接受不同预处理方案，进行同基因外周血干细胞移植。所有供者均为患儿的同卵双胎同胞，并经重组人粒细胞集落刺激因子(rhGCSF)动员。 结果4例患儿接受干细胞(MNC)平均数量为10.08×108/kg。白细胞及血小板平均植入时间分别为10.7d及12.3d，无明显移植并发症。病例4随诊5个月后复发，放弃治疗2个月后死亡，余病例均存活，可正常生活，随诊时间均在16个月以上。 结论同基因外周血干细胞移植可以作为治疗包括白血病在内的多种血液病的有效方法，但其远期效果还有待进一步评估。

关键词: 同基因外周血干细胞移植, 儿科, 白血病, 再生障碍性贫血

Abstract: AbstractObjectiveTo investigate the outcome,engraftment and prognosis of syngeneic peripheral stem cell transplantation in pediatric leukemia and aplastic anemia. MethodsFour cases who suffered from chronic myeloid leukemia (CP),acute myeloid leukemia (M2),severe aplastic anemia,and acute lymphoblastic leukemia(Ph+) were analyzed,respectively.Three leukemia patients achieved the first complete remission.after the regular chemotherapy.Conditioning regimens were all different.All donors who received rhGCSF mobilization were identicaltwins. ResultsThe average amount of MNC is 10.08×108/kg.The engraftment of WBC and PLT were +10.7d and +12.3d,respectively.No severe toxicity and infection were observed.Case 4 relapsed 5 months post transplantation,and died due to no further therapy.Other cases were well.Follow up time was more than 16 months. ConclusionSyngeneic peripheral stem cell transplantation is the effective method to treat some kinds of blood disorders,including leukemia.However,the future effect needs to be evaluated.

Key words: Aplastic anemia , Pediatric, Leukemia