关键词: 肾小球疾病, 病理学, 活组织检查, 婴幼儿

Abstract: AbstractObjectiveTo understand the relationship between pathological features and clinical manifestations in children under 3 years suffering from renal glomerular disease in Hunan Province. MethodsRenal biopsy by rapid percutaneous punctuation was performed on 73 children under the age of 6 years who were all diagnosed clinically as kidney diseases of 10 different kinds totally.The specimens were divided into 3 parts for microscope,electronmicroscope and immunofluorescence examination separately and processed by HE,PAS,PASM and Masson staining.Immunofluorescence was used to detect the deposition of IgG,IgM,IgA,C3,C4,C1q and fibrin in renal tissue.Additional examinations were done to detect HBsAg and HBcAg deposition in some cases with positive serum HBsAg. ResultsAll the renal biopsy performances were successful.The most common pathological type (51/73,69.86%) was mesangial proliferation glomerulonephritis (MsPGN).Diseases with similar clinical features might present different pathological types,and the similar pathological type might be seen in diseases with different clinical manifestations. ConclusionRenal biopsy is of great value for the diagnosis,treatments and estimation of prognosis for kidney disease in infants.Electron microscope examination plays an important role in pathological diagnosis,too.

Key words: Biopsy, Infants , Pathology