中国实用儿科杂志

中国实用儿科杂志

• 论著 • 上一篇    下一篇

脑脊液细胞学检查170例分析

孙素真，施荣富，王春香，张风珍   

  1. 河北省儿童医院神经内科，石家庄 050031
  • 收稿日期:2006-02-07 修回日期:2006-03-25 出版日期:2006-07-06 发布日期:2006-07-06

Assessment of cerebrospinal fluid cytology in 170 children.

Sun Suzhen,Shi Rongfu,Wang Chunxiang,et al.   

  1. Department of Neurology,Children Hospital of Hebei Province,Shijiazhuang 050031,China
  • Received:2006-02-07 Revised:2006-03-25 Online:2006-07-06 Published:2006-07-06

摘要： 目的总结170例脑脊液(CSF)细胞学的检查结果，分析其在小儿神经系统疾病或具有中枢神经系统表现疾病诊断中的临床意义。 方法2000-06—2004-04河北省儿童医院对170例患儿进行CSF细胞学检查，CSF标本经玻片离心法制片，常规采用迈格姬染色后观察。 结果CSF细胞学检查结果发现包括特异性病原体与恶性肿瘤，共4例，占全部CSF检查的23%，其中新型隐球菌2例，脑膜白血病2例。跟踪观察治疗前后CSF细胞学变化89例，其中结核性脑膜炎20例，化脓性脑膜炎29例，病毒性脑炎40例，治疗前后CSF细胞学检查主要表现为细胞成分及数量的变化。 结论CSF细胞学检查对小儿神经系统疾病的临床诊断和治疗有重要意义，其特异性发现恶性肿瘤主要为脑膜白血病，病原体以新型隐球菌多见。脑脊液细胞学检查能直接、客观地评价临床疗效。

关键词: 脑脊液, 细胞诊断学, 小儿疾病

Abstract: To study one experiment room 's cerebrospinal fluid cytology results from 170 specimens. MethodsA retrospective study of 170 cytology specimens was done between 2000 and 2004.The MayGrunwaldGiemsa 'stain was applied to routine cytology. ResultsA total of 170 CSF specimens were interpreted.Specific findings were identified in 4 specimens and analyse its significance in children with diseases of central nervous system.Specific infectious organisms were identified in specimens:cryptococcus was the most common infectious agent observed (n=2),metastatic leukemia (n=2).The changes of 89 specimens were observed before and after treatment,including 20 cases of cerebral tuberculosis,29 cases of purulent meningitis and 40 cases of virogenetic encephalitis.The main changes were components and amounts of cells in CSF before and after treatment. ConclusionAlthough specific findings in CSF cytology account for a small percentage of total specimens,they are of great significance in reaching final diagnoses.The most commonly identified malignancy is metastatic leukemia.The most commonly identified infectious organism was cryptococcus.The clinical results after treatment might be assessed directly and objectively by CSF cytology.

Key words: Diseases in children , Cytology