关键词: 托吡酯, 戊四氮, 癫疒间, 胰岛素, 胰岛素样生长因子1

Abstract: To study the effects of topamax on the serum level of insulin,the expression of insulinlike growth factor1 in hippocampus,and also their relationship with weight changes in pentetruzoleinduced epileptic rats.To explore the mechanism in which topamax causes the reduction of the rats weights. MethodsFrom Mar.2005 to Sep.2005 114 Wistar rats were randomly divided into four groups:the blank control group,the TPM contrast group,the PTZ model group and the TPM treated group.Weight changes were measured every 3 days.The level of serum insulin and the expression of IGF1 in hippocampus were surveyed,using the method of radioimmunity and the immunohistochemical method respectively on the 2nd、the 4th and the 6th weekends. ResultsTPM contrast group and TPM treated group showed the reduction of the rats’ weights,comparing with the other two groups on the 3rd weekend,and then fell to the nadir on the 4th weekend(P<005).Serum insulin descended clearly but IGF1 in hippocampus rose clearly on the 4th weekend,comparing the TPM contrast group、the PTZ group and the TPM treated group with the blank group,also the TPM treated group with the blank group(P<005).The level of IGF1 in hippocampus rose clearly on the 6th weekend,comparing the TPM treated group with the blank group,the TPM contrast group and the PTZ group(P<005). ConclusionTopamax can reduce the weights of rats,but not by reducing the level of serum insulin and raise the level of insulinlike growth factor1 in hippocampus.Moreover,it needs further study whether the descending of the level of serum insulin and the rising of the level of insulinlike growth factor1 in hippocampus in epileptic rats both participate in the process of pathophysiology of epilepsy.

Key words: Insulin, Insulinlike growth factor1 , Pentylenetetrazol, Epilepsy