关键词: 宫内发育, 低出生体重, 子代

Abstract: AbstractObjectiveTo identify the impact that birth weights of parents exert on the birth weights of offsprings and to report some evidences of genetic and environmental influence on human birth weight. MethodsThe study was done from 1995 to 2001 retrospectively.The subjects were from the cohort of Intrauterine Programming and Adult Diseases (totaling 975 cases,494 males,481 females),who were born during 1948~1954 in Peking Union Hospital.The data was based on the clinical birth report from the hospital and selfreport from subjects by questionnaire.The correlations of birth weight between parents and offsprings were compared and analyzed. ResultsThe influence from maternal parity,parturition age,and the height and weight of her spouse being controlled,there was a significant positive correlation (r=0.32,P<0.001)of birth weight between mothers’ and their offsprings'.The Odds Ratio of low birth weight in the first born child was 3.7 whose mother was low birth weight,with mother ’s birth weight being above 3500 g as reference.But there is no relationship of gestational age between mothers and offsprings.And the correlation of birth weight and gestational age between fathers and their offsprings was not observed. ConclusionTo some extent,the mothers with low birth weight may impose the adverse effect of her poor intrauterine programming on her offsprings' fetal growth.

Key words: Offspring , Low birth weight