关键词: 肥胖, 氧化应激, 抗氧化剂, 抗氧化酶, 丙二醛

Abstract: AbstractObjectiveTo investigate whether obesity might cause increased oxidative stress in the bodies of obese children,and to explore its possible mechanism. MethodsFrom Oct.2004 to Mar.2005,eighty obese children (OCs),and eighty healthy children (HCs) whose age and others,except for body mass index (BMI),were matched with the OCs,were enrolled in a casecontrol study,in which the levels of vitamin C (VC),vitamin E (VE),and βcarotene (βCAR) in plasma,as well as the activities of superoxide dismutase (SOD),catalase (CAT),and the level of malondialdehyde (MDA) in erythrocytes were determined by spectrophotometry. ResultsCompared with the average values of VC,VE,βCAR,SOD,CAT,and MDA in the HCs group,the average values of VC,VE,βCAR,SOD,and CAT in the OCs group were significantly decreased (P<0.001),and the average value of MDA in the OCs group was significantly increased (P<0.001).The findings from the partial correlation analysis between BMI and VC,VE,βCAR,SOD,CAT,and MDA for 80 OCs while controlling the age and the course of disease suggested that with increased BMI the values of VC,VE,βCAR,SOD,and CAT were gradually decreased (P<0.05~0.01),and MDA was gradually increased (P<0.001).The findings from the reliability analysis for VC,VE,βCAR,SOD,CAT,and MDA used to reflect increased oxidative stress in the OCs showed that the reliability coefficients (alpha,6 items) = 0.7231,P<0.0001,and that the standardized item alpha = 0.9207,P<0.0001. ConclusionThe findings in the present study suggest that there exists an increased oxidative stress in the bodies of obese children,and such phenomena are closely correlated with increased BMI in the obese children.

Key words: Antioxidative enzyme, Malondialdehyde , Oxidative stress, Antioxidant