关键词: 硫化氢, 一氧化氮, 海拔

Abstract: AbstractObjectiveTo explore the difference in the contents of gasotransmitters nitric oxide (NO) and hydrogen sulfide (H2S) in healthy children in areas of different altitudes. MethodsForty-two healthy children were divided by different altitudes.Seventeen children (11 boys and 6 girls,at the age of 7.28±4.79) were from the area of Beijing (the average altitude is 43.5 metres) and 25 (12 boys and 13 girls,at the age of 10.42±0.49) from Haibei state in Qinghai province (the average altitude is above 3200 metres).The serum was sampled on a fasting state.The contents of NO and H2S in the serum were measured by Griess and sensitive sulfur electrode. ResultsThe content of NO in the serum of healthy children in the area of Beijing was 60.58±16.85 μmol/L,which was much lower then that of Haibei state in Qinghai province (73.88±18.97 μmol/L); the content of H2S in the serum of healthy children in the area of Beijing was 65.55±9.07 μmol/L,which was much higher than that of Haibei state in Qinghai province (46.92±6.46 μmol/L). ConclusionThe content of NO in the serum of healthy children in the area of high altitude is much higher than that in the area of low altitude,while the content of H2S in the serum of healthy children in the area of high altitude is much lower than that in the area of low altitude.

Key words: Altitude , Nitric oxide