中国实用儿科杂志

中国实用儿科杂志

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Tourette综合征的发病危险因素分析

徐惠琴a,金嵘b,郑荣远a,张磊a,邵蓓a,何金彩a,王旭华a   

  1. 温州医学院附属一院 a神经内科 b流行病学教研室，浙江温州325000
  • 收稿日期:2006-08-12 修回日期:2006-11-23 出版日期:2007-03-06 发布日期:2007-03-06

An analysis of the risk factors of Gilles de la Tourette syndrome.

XU Huiqin*,JIN Rong,ZHENG Rongyuan,et al.   

  1. Department of Neurology,First Affiliated Hospital，Wenzhou Medical College,Wenzhou 325000,China
  • Received:2006-08-12 Revised:2006-11-23 Online:2007-03-06 Published:2007-03-06

摘要： 目的探讨Tourette综合征(TS)发病的危险因素。 方法200001—200412采用病例对照研究的方法，对温州医学院附属一院100例TS患儿及100名对照病例的相关资料进行非条件Logistic回归和主成分分析。 结果非条件Logistic回归多因素分析显示，该病有统计学显著性意义的危险因素是TS家族史、注意缺陷伴多动障碍(ADHD)、过敏性哮喘、母亲孕早期受精神刺激、高热(T>39℃)和极低频磁场暴露，其标准回归系数分别为1.3987、3.6385、1.7657、1.7250、1.8973和1.0677。主成分分析提取了4个主成分，其方差累积贡献率为57.025%。 结论TS的发病与遗传因素和环境因素有关。

关键词: Tourette综合征, 危险因素, 非条件Logistic回归, 主成分分析

Abstract: AbstractObjectiveTo explored the risk factors of Gilles de la Tourette syndrome(TS). MethodsTotally 100 cases with TS and 100 controls were investigated through casecontrol study.Data was analyzed with nonconditional logistic regression and principal component analysis. ResultsResults from nonconditional logistic regression showed that such cases were associated with following factors:family history of TS,attention deficit hyperactivity disorder (ADHD),allergic asthma,nocuous mental stimulation during early pregnancy,high fever(T>39℃),exposure to pole low frequent electromagnetism field.The standard regression coefficients were 1.3987、3.6385、1.7657、1.7250、1.8973 and 1.0677，respectively.Four principal components were extracted through principal component analysis,and the cumulative contribution of variances of the 4 principal components was 57.025%. ConclusionThe risk factors of TS are related to the concomitance of genetic factors and environmental factors.

Key words: Principal component analysis , Risk factors, Nonconditional logistic regression