中国实用儿科杂志

中国实用儿科杂志

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宫内发育迟缓早产儿胰岛素 生长激素及皮质醇的变化和发病关系研究

姚明珠，陆国强，陈豪，印学蕾，吴莉，戴芸佳，郭佳林，丁效薇，胡勇，徐秋玲   

  1. 上海市第一妇婴保健院儿科暨上海市早产儿医疗
  • 收稿日期:2006-06-10 修回日期:2006-10-15 出版日期:2007-01-06 发布日期:2007-01-06

Studies on the relations between changes of insulin、growth hormone and cortisol in premature infants with intrauterine

growth retardation.YAO Mingzhu，LU Guoqiang，CHEN Hao，et al.   

  1. Department of Neonatology, Shanghai First Maternity and Infant Hospital, Shanghai 200040,China
  • Received:2006-06-10 Revised:2006-10-15 Online:2007-01-06 Published:2007-01-06

摘要： 摘要】目的探讨胰岛素(Ins)、生长激素(GH)、皮质醇(Cor)与早产儿宫内发育迟缓 (IUGR)的关系。方法采用放射免疫分析法检测40例IUGR早产儿和45例适于胎龄早产儿(对照组)母血、脐血和生后7日龄血清中的Ins、GH、Cor含 量，并进行分析比较。结果Ins在IUGR组脐血、生后7日龄血清中的含量明显低于对照组(P<0.05)。GH、Cor在母血中含量明显低于对照组 (P<0.05)。而脐血、生后7日龄血清中Cor含量在IUGR高于对照组，但二组比较差异无显著性(P>0.05)。结论早产儿IUGR与Ins、GH、Cor等内分 泌激素有关，它们通过调节代谢而影响胎儿宫内的生长发育，发挥着较重要的作用。

关键词: 宫内发育迟缓, 早产儿, 胰岛素, 生长激素, 皮质醇

Abstract: AbstractObjectiveTo investingate the relations of insulin(Ins)、growth hormone (GH) and cortisol (Cor) with intrauterine growth retardation (IUGR).MethodsBlood samples were collected from mothers、umbilical cord and 7day infants in forty cases of premature infant with IUGR and fortyfive cases of appropriate for gestational age infant(AGA),and the concentrations of Ins、GH and Cor were measured by radioimmunoassay, and the results were analyzed and compared.ResultsThe serum Ins of umbilical cord and 7day infant in IUGR group were significantly lower than those in the control group (P<0.01). The maternal serum GH、Cor in IUGR group were significantly lower than those in the control group (P<0.05). There was no significant difference of serum Cor in umbilical cord and 7day infant between IUGR group and control group (P>0.05).ConclusionThe change of Ins、GH and Cor levels in maternal、umbilical and 7day infant serum may play an important role in the pathophysiological changes in IUGR of premature infants.

Key words: Growth hormone, Cortisol , Premature infant, Insulin