关键词: 葡萄糖6磷酸脱氢酶, 高胆红素血症, 发病时间, 发生率, 缺乏程度

Abstract: AbstractObjectiveTo research into the morbidity and characteristics of hyperbilirubinemia which develops among the G6PD (glucose6 phosphate dehydrogenate) deficiency neonates.MethodsDetermine the G6PD with umbilical blood of the mature healthy neonates who were delivered in the resent 5 years in the Obstetrical Department of our hospital.Study the morbidity and invasiontime of hyperbilirubinemia according to their sex and the deficiency extent of the enzymatic activity in the G6PD deficiency infants.Results(1) 82 cases developed hyperbilirubinemia in the 418 G6PD deficiency infants,accounted for 19.62%. (2) In the G6PD deficiency patientinfants,the enzymatic activity was much lower in male cases than in female cases (P<0.01);the morbidity of hyperbilirubinemia was much higher in male cases than in female cases (P<0.01); the morbidity took on a notable difference among the three different enzymatic activity deficiency teams (P<0.05); in the G6PD deficiency infants,the hyperbilirubinemia occurred mainly in one week after birth.ConclusionIn neonatal period,the morbidity of hyperbilirubinemia is higher in the G6PD deficiency infants.The characteristics are:the disease occurs more frequently in male infants than in female infants,and the more deficiency,the higher morbidity.The peek time when G6PD deficiency infants develop hyperbilirubinemia is in 2~4 days after birth.

Key words: Morbidity, Degree of deficiency , Hyperbilirubinemia, Invasion time