中国实用儿科杂志

中国实用儿科杂志

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托吡酯治疗前后癫疒间患儿内分泌激素的变化及分析

王如明1,刘华卫2,温兆春1,王学禹1,高玉兴1,孙文秀1   

  1. 1山东省立医院儿科(济南，250021) 2山东大学齐鲁医院儿科(济南，250021)
  • 收稿日期:2005-03-20 修回日期:2005-05-30 出版日期:2005-09-25 发布日期:2005-09-25

Effects of topamax on certain endocrine-hormones in children with epilepsy.

Wang Ruming,Liu Huawei,Wen Zhaochun,et al.   

  1. Pediatric Department.Shandong Provincial Hospital,Jinan 250021,China
  • Received:2005-03-20 Revised:2005-05-30 Online:2005-09-25 Published:2005-09-25

摘要： 目的探讨托吡酯对癫疒间患儿部分内分泌功能的影响。 方法于2003年6月~2004年6月对山东省立医院儿科符合癫疒间诊断的36例患儿分别于治疗前、治疗3个月、治疗6个月测量血中部分内分泌激素，并对其进行比较。 结果血三碘甲状腺氨酸(T3)在治疗3个月时较治疗前明显增高(P<0.05)，6个月时增高不明显；而胰岛素、皮质醇、C-肽在治疗3个月、6个月时则明显降低(P<0.05)，但在治疗3、6个月之间T3、胰岛素、皮质醇、C-肽并无明显变化；T4、TSH、生长激素在治疗过程中无明显变化；体重指数在治疗3个月时明显下降，6个月时又有所回升。 结论托吡酯对生长激素无明显影响，不影响儿童的生长发育。

关键词: 托吡酯, 癫疒间, 内分泌激素, 体重指数

Abstract: To study the effects of Topamax on certain endocrine hormones in children with epilepsy. MethodsThe concentrations of certain blood endocrine-hormones were determined and compared in 36 children with epilepsy at the be ginning,the end of the third and the end of the sixth therapeutic month. ResultsTriidiothyronine(T3) levels were significantly higher at the end of the third month than the beginning (P<0.05),but were not increased obviously at the end of the sixth therapeutic month.Insulin(INS),corticol(F),and C-peptide(C-P) concentrations were significantly lower at the end of the third and the end of the sixth therapeutic month than the beginning(P<0.05),whereas they remained unaltered between the end of the third and the end of the sixth therapeutic month.Thyroxine(T4),thyroid stimulating hormone(TSH) and growth hormone(GH) concentrations were not significantly changed during the course of the therapy.Body mass index(BMI) was significantly reduced at the end of the third therapeutic month,while it returned a little at the end of the sixth therapeutic month. ConclusionTopamax has no significant effect on growth hormone,so it doesn't afect children's growth and development.

Key words: Body mass index , Epilepsy, Endocrine-hormones