中国实用儿科杂志 ›› 2026, Vol. 41 ›› Issue (2): 116-120.DOI: 10.19538/j.ek2026020606

• 专题笔谈 • 上一篇    下一篇

儿童过敏原检测的临床选择与结果解读

  

  1. 华中科技大学同济医学院附属同济医院过敏反应科,湖北  武汉  430030
  • 出版日期:2026-02-06 发布日期:2026-03-13
  • 通讯作者: 祝戎飞,电子信箱:zrf13092@163.com
  • 基金资助:
    国家重点研发计划项目(2023YFC250790)

Clinical selection and result interpretation of allergen testing in children

  1. Department of Allergy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan  430030,China
  • Online:2026-02-06 Published:2026-03-13

摘要: 过敏性疾病是儿童最常见的慢性疾病之一,其全球患病率呈显著上升趋势。过敏原检测是诊断过敏性疾病、明确致病原因、从而制定精准防控与特异性免疫治疗方案的核心。然而,儿童并非缩小版的成人,其免疫系统处于动态发育中,临床表现不典型,检测结果解读更具复杂性。该文旨在系统介绍儿童过敏原检测的常用方法,包括体内试验和体外试验的原理与特点;重点探讨在特应性皮炎、食物过敏、过敏性鼻炎与哮喘、严重过敏反应等临床场景下如何合理选择检测策略;并深入阐述如何结合患儿的年龄、临床表现、暴露史、地域特征等因素对检测结果进行解读,避免误诊与过度诊断。该文将对分子过敏原诊断、生物标志物等新技术在儿童过敏领域的应用前景进行展望,以期为临床工作提供最新的实践参考。

关键词: 过敏原检测, 皮肤点刺试验, 特异性 IgE, 组分解析诊断

Abstract: Allergic diseases are among the most common chronic disorders in children,and their global prevalence has been rising markedly.Allergen testing is central to confirming the diagnosis,identifying the pathogenic causes,and formulating the core of precision prevention and control as well as specific immunotherapy plans.Children,however,are not“small adults”;their immune system is undergoing dynamic maturation,their clinical symptoms are often atypical,and the interpretation of test results is therefore intrinsically more complex.This article systematically introduces the common ways of allergen testing in children,including the principles and characteristics of both in-vivo and in-vitro assays.It focuses on how to rationally select an optimal testing strategy in specific clinical scenarios such as atopic dermatitis,food allergy,allergic rhinitis and asthma, and severe anaphylaxis.Further discussion is focused on how to interpret the test results based on patient age,clinical presentation,exposure history,regional features and other confounders to avoid misdiagnosis and over-diagnosis. Finally,the application prospect of emerging technologies is looked forward to, including molecular allergen diagnosis and novel biomarkers,with the aim of providing clinicians with an up-to-date evidence-based reference.

Key words: allergen testing, skin prick test, specific IgE, componentresolved diagnosis