Abstract:

Abstract：Objective To explore the relationship between plasma homocysteine levels and the carotid plaque stability in the elderly population.Methods A total of 1106 outpatients and inpatients with carotid plaque examined by ultrasound examination during September 1st 2012 to April 31st 2014 were included.Detected the Plasma homocysteine levels of patients and all of them were examined the carotid plaque by ultrasonography.Logistic regression models were used to assess the associations of homocysteine levels and carotid plaque stability.Results The distributions of gender，age，history of hypertension between the stable and unstable carotid plaques were significantly different.Logistic regression results showed that Plasma homocysteine levels was significantly associated with carotid plaque stability after adjusting for age，sex and other potential confounders.Conclusion Plasma level of homocysteine may be associated with unstable carotid plaque in the elderly population.The higher plasma homocysteine levels，the greater risk of unstable carotid plaque.

Key words: elderly population, homocysteine, carotid plaque

摘要：

目的 研究中老年人群血浆同型半胱氨酸与颈动脉斑块稳定性的关系。方法 2012年9月1日至2014年4月31日在天津市人民医院神经内科住院患者，符合纳入与排除标准1106例患者为研究对象，评估颈动脉斑块及测量的血浆同型半胱氨酸水平。采用Logistic回归分析血浆同型半胱氨酸与颈动脉斑块稳定性的关系。结果 不同性质的颈动脉斑块患者中性别、年龄、高血压史的分布不同(P<0.05)。Logistic回归结果显示，在校正了年龄、性别及高血压等混杂因素后，血浆同型半胱氨酸与颈动脉斑块的稳定性相关。结论 中老年人群血浆同型半胱氨酸与颈动脉斑块的稳定性有关，血浆同型半胱氨酸越高发生不稳定性颈动脉斑块的风险越大。

关键词: 中老年人群, 同型半胱氨酸, 颈动脉斑块