[1]中华医学会糖尿病学分会.基于胰高血糖素样肽1降糖药物的临床应用共识[J].中华糖尿病杂志,2014,6(1):14-20. [2]Thorens B,Waeber G.Glucagon-like peptide-I and the control of insulin secretion in the normal state and in NIDDM[J].Diabetes,1993,42(9):1219-1225. [3]Wei Y,Mojsov S.Tissue-specific expression of the human receptor for glucagon-like peptide-I:brain,heart and pancreatic forms have the same deduced amino acid sequences[J].FEBS Lett,1995,358(3):219-224. [4]Yamato E,Ikegami H,Takekawa K,et al.Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1) [J].Horm Metab Res,1997,29(2):56-59. [5]Bunck MC,Diamant M,Corner A,et al.One-year treatment with exenatide improves beta-cell function,compared with insulin glargine,in metformin-treated type 2 diabetic patients:a randomized,controlled trial[J].Diabetes Care,2009,32(5):762-768. [6]Vilsboll T,Brock B,Perrild H,et al.Liraglutide,a once-daily human GLP-1 analogue,improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus[J].Diabet Med,2008,25(2):152-156. [7]Zinman B,Gerich J,Buse JB,et al.Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD) [J].Diabetes Care,2009,32(7):1224-1230. [8]Russell-Jones D,Vaag A,Schmitz O,et al.Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU):a randomised controlled trial[J].Diabetologia,2009.52(10):2046-2055. [9]DeFronzo RA,Ratner RE,Han J,Kim DD,Fineman MS,Baron AD.Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.Diabetes Care,2005,28(5):1092-1100. [10]Nauck M,Frid A,Hermansen K,et al.Efficacy and safety comparison of liraglutide,glimepiride,and placebo,all in combination with metformin,in type 2 diabetes:the LEAD (liraglutide effect and action in diabetes)-2 study[J].Diabetes Care,2009,32(1):84-90. [11]Garber A,Henry R,Ratner R,et al.Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono):a randomised,52-week,phase Ⅲ,double-blind,parallel-treatment trial[J].Lancet,2009,373(9662):473-481. [12]Yang W,Chen L,Ji Q,et al.Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China,South Korea and India:a 16-week,randomized,double-blind,active control trial[J].Diabetes Obes Metab,2011,13(1):81-88. [13]Ussher JR,Drucker DJ.Cardiovascular actions of incretin-based therapies[J].Circ Res,2014,114(11):1788-1803. [14]Drucker DJ,Buse JB,Taylor K,et al.Exenatide once weekly versus twice daily for the treatment of type 2 diabetes:a randomised,open-label,non-inferiority study[J].Lancet,2008,372(9645):1240-1250. [15]Wang B,Zhong J,Lin H,et al.Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide:a meta-analysis of clinical trials[J].Diabetes Obes Metab,2013,15(8):737-749. [16]Scholte M,Timmers L,Bernink FJ,et al.Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI):study protocol for a randomized controlled trial[J].Trials,2011,12:240. [17]Kahn SE,Cooper ME,Del PS.Pathophysiology and treatment of type 2 diabetes:perspectives on the past,present,and future[J].Lancet,2014,383(9922):1068-1083. [18]Armstrong MJ,Houlihan DD,Rowe IA,et al.Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes:individual patient data meta-analysis of the LEAD program[J].Aliment Pharmacol Ther,2013,37(2):234-242. [19]Owens DR,Monnier L,Bolli GB.Differential effects of GLP-1 receptor agonists on components of dysglycaemia in individuals with type 2 diabetes mellitus[J].Diabetes Metab,2013,39(6):485-496. [20]Kielgast U,Holst JJ,Madsbad S.Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual beta-cell function[J].Diabetes,2011,60(5):1599-1607. [21]Varanasi A,Bellini N,Rawal D,et al.Liraglutide as additional treatment for type 1 diabetes[J].Eur J Endocrinol,2011,165(1):77-84. [22]Shehadeh N,Daich E,Zuckerman-Levin N.Can GLP-1 preparations be used in children and adolescents with diabetes mellitus[J].Pediatr Endocrinol Rev,2014,11(3):324-327. [23]Li L,Shen J,Bala MM,et al.Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus:systematic review and meta-analysis of randomised and non-randomised studies[J].BMJ,2014,348:g2366. [24]Devaraj S,Maitra A.Pancreatic Safety of Newer Incretin-Based Therapies:Are the “-tides” Finally Turning[J].Diabetes,2014,63(7):2219-2221. |