Abstract: Objective    To prepare a new-type numerical control cutting resin material for complete denture base and evaluate its mechanical and biological properties. Methods    In the research group，a new-type computer numerical control cutting resin material for complete denture base was prepared by mixing，heating，compression and shaping，while the control group was prepared with traditional thermosetting base resin materials. Then，the differences in flexural strength，flexural elastic modulus，water absorption value and dissolution value between the two groups were compared. The material of study group was cultured with L929 cells. Extract of the new material was extracted and diluted，which were recorded as 100%，75%，50% and 25% extract groups，respectively. Positive，negative and blank control groups were set up to test their cytotoxicity. Results    The new-type computer numerical control cutting resin disc for complete denture base prepared by the research group had smooth surface，no impurities，no pores，and uniform color. The flexural strength of the research group ［（101.09 ± 1.69）MPa ］ was higher than that of the control group ［（68.84 ± 3.59）MPa ］，and the flexural elastic modulus of the research group ［（2736.00 ± 67.93）MPa ］ was also higher than that of the control group ［（2064.00 ± 73.98）MPa ］，and the differences were statistically significant（t values were 16.245 and 8.299，respectively，P < 0.05）. The water absorption value of the research group ［（17.14 ± 0.28）μg/mm3 ］ was lower than that of the control group ［（20.50 ± 1.82）μg/mm3 ］，and its dissolution value ［（1.32 ± 0.51）μg/mm3 ］ was also lower than that of the control group ［（2.07 ± 0.49）μg/mm3 ］，the differences being statistically significant（t values were 2.271 and 0.924，respectively，P < 0.05）. Except the positive control group，whose cytotoxicity grade was 3，the cytotoxicity of other groups was grade 0 or grade 1，and the results of in vitro cytotoxicity test were qualified. Conclusion    The new-type computer numerical control cutting resin materials for complete denture base are better than the traditional materials by heating and shaping，and has no potential cytotoxicity，which meet the clinical requirement of the base material for digital complete denture.

Key words: digital manufacture, base resin material, mechanical properties, biological properties

摘要： 目的    制备一种新型数控切削全口义齿基托树脂材料，初步评价其力学性能和生物学性能。方法    研究组采用捏炼混合、加热加压成型固化的方法制备新型数控切削全口义齿基托树脂材料，对照组使用传统热凝基托树脂材料进行制备，比较两组的挠曲强度、挠曲弹性模量、吸水值和溶解值差异。将研究组材料与L929细胞共培养，提取材料浸提液并进行稀释，分别记为100%、75%、50%、25%浸提液组，并设置阳性、阴性和空白对照组，检测其细胞毒性。结果    研究组制备完成的新型数控切削全口义齿基托树脂盘表面光滑，无杂质和气孔，色泽均匀。研究组挠曲强度［（101.09 ± 1.69）MPa ］高于对照组［（68.84 ± 3.59）MPa］，其挠曲弹性模量［（2736.00 ± 67.93）MPa ］也高于对照组［（2064.00 ± 73.98）MPa］，差异均有统计学意义（t值分别为16.245、8.299，均P < 0.05）；研究组的吸水值［（17.14 ± 0.28）μg/mm3］低于对照组［（20.50 ± 1.82）μg/mm3］，其溶解值［（1.32 ± 0.51）μg/mm3］也低于对照组［（2.07 ± 0.49）μg/mm3］，差异均有统计学意义（t值分别为2.271、0.924，均P < 0.05）。除阳性对照组的细胞毒性分级为3级外，其他组均为0级或1级，体外细胞毒性检测结果为合格。结论    新型数控切削全口义齿基托树脂材料的性能优于传统热凝固化的全口义齿基托树脂材料，且不具有潜在的细胞毒性，能够满足数字化全口义齿基托材料的临床要求。

关键词: 数字化加工, 基托树脂材料, 力学性能, 生物学性能