Abstract: Objective    To observe the clinical efficacy of semiconductor diode laser combined with 5-fluorouracil for epulis. Methods    Totally 38 patients who were diagnosed with epulis at the Stomatology Center of Shenzhen People′s Hospital from January 2017 to June 2018 were randomly divided into a group of simple semiconductor laser surgery （laser group）and a group of semiconductor laser combined with 5-fluorouracil treatment （laser combined 5-fluorouracil group），19 cases in each group. Follow-up was performed for 12 months, and the cure rate and recurrence of the two groups were compared. Results    In the laser combined with 5-fluorouracil group，19 cases were cured with a cure rate of 100%. Fifteen cases were cured in laser group and 4 cases recurred，and the cure rate was 78.9%. The difference in cure rate between the two groups was statistically significant（P = 0.035）. Postoperative pathological results of 38 patients were as follows：there were 26 cases of vascular epulis，8 cases of fibrous epulis and 4 cases of granulomatous epulis.  Conclusion    Epulis has a tendency to recur. Local injection of semiconductor diode laser combined with 5-fluorouracil has good therapeutic effect and can significantly reduce the recurrence rate of epulis，which is worthy of clinical promotion.

Key words: semiconductor diode laser, epulis, 5-fluorouracil

摘要： 目的　探讨半导体激光联合5-氟尿嘧啶治疗牙龈瘤的临床疗效。 方法    选择2017年1月至2018年6月于深圳市人民医院口腔医学中心就诊的牙龈瘤患者38例， 随机分为单纯半导体激光手术治疗组（激光组）和半导体激光联合5-氟尿嘧啶治疗组（激光联合5-氟尿嘧啶组），每组19例。术后随访12个月，比较两组的治愈率和复发情况。结果　激光联合5-氟尿嘧啶组治愈19例，治愈率为100%；激光组治愈15例，复发4例，治愈率为78.9%；两组治愈率差异有统计学意义（P = 0.035）。38例患者术后病理结果：血管型26例，纤维型8例，肉芽肿型 4例。结论　牙龈瘤具有复发倾向，应用半导体激光照射联合5-氟尿嘧啶局部注射，治疗效果好且可明显降低复发率，值得临床推广。

关键词: 半导体激光, 牙龈瘤, 5-氟尿嘧啶