Abstract:

 Periodontitis is a polymicrobial community-induced chronic inflammatory disease， and the destruction of the periodontium is associated with the inflammation of host immune response. Evidences from studies indicate that the complement system involves in the pathogenesis of periodontitis. P.gingivalis can manipulate the complement system to subvert host immunity and remodel a symbiotic microbiota into a dysbiotic state， resulting in the develoment of periodontitis. As a result， further understanding of the mechanism of P.gingivalis in manipulating the complement system in the pathogenesis of periodontitis may provide a new approach to the treatment of periodontitis.

Key words: P.gingivalis, C5a receptor, C3 receptor, dysbiosis

摘要：

牙周炎作为一种由多种微生物诱发的慢性炎症性疾病，其造成的牙周组织损伤常与宿主免疫反应所引发的炎症相关。研究发现，补体系统参与牙周炎的发生与发展，牙龈卟啉单胞菌（P.gingivalis）可以利用补体成分破坏宿主的免疫防御，造成牙周微环境失调，进而诱发牙周炎的发生。因此，探究P.gingivalis利用补体诱发牙周微环境失调的作用机制，可以为今后牙周治疗的防治提供新的途径。

关键词: 牙龈卟啉单胞菌, C5aR, CR3, 微环境失调