Abstract:

Stem cells of apical papilla are successfully isolated and cultured in vitro in recent years.It has strong ability of proliferation and differentiation. Also，it is a seed cell in tissue engineering tooth regeneration research.The biological properties of stem cells of apical papilla are influenced by many external factors， such as growth factors，signaling pathway， physical factors， scaffold material and so on. Based on the existing literature，this paper reviews the effects of growth factors on the proliferation and differentiation of stem cells of apical papilla.

Key words: stem cells of apical papilla, growth factors, proliferation, differentiation

摘要：

根尖牙乳头干细胞是近几年体外成功分离培养的新型牙源性干细胞，具有较强的增殖及多向分化能力，是组织工程牙再生研究中具有很大潜能的种子细胞。根尖牙乳头干细胞的生物学性能易受到许多外源性因素的影响，如生长因子、信号通路、物理因素、支架材料等。本文基于现有文献从生长因子对根尖牙乳头干细胞增殖及分化的影响方面做一综述。

关键词: 根尖牙乳头干细胞, 生长因子, 增殖, 分化