Abstract:

Objective    To evaluate the distribution of the space between hydroxyapitite particle from 3 types of sizes by Micro-CT and the clinical effect. Methods    From March to April 2014，Micro-CT laboratory，Guangzhou Scientific City，Micro-CT scanning was performed for 3 different diameters of hydroxyapitite particle，0.25 ~ 1 mm，0.4 ~ 1 mm，1 ~ 2 mm respectively by packed in vitro. Results    Group 1 ~ 2 mm particle showed loose and irrregular distribution，the space rate 61.75%；groups 0.25 ~ 1 mm and 0.4 ~ 1 mm showed uniform and compact distribution，the space rate 27.33% and 42.44%. Conclusion    Micro-CT is a practical method for studying graft material partical；group 0.25 ~ 1 mm is fit for clinic for its uniform and compact distribution.

Key words: micro-CT, bone graft, particle, space, hydroxyapitite

摘要：

目的    通过显微CT体外评价，比较3种不同直径羟磷灰石颗粒外部间隙分布情况，探讨材料外部间隙对临床运用的影响。方法    2014年3—4月于广州科学城显微CT实验室对颗粒直径分别为0.25 ~ 1 mm、0.4 ~ 1 mm、1 ~ 2 mm的3种人工骨材料进行体外固定，采用显微CT扫描，评价各自的间隙排列。结果    1 ~ 2 mm组羟基磷灰石颗粒压实堆积后显微CT下显示材料颗粒排列松散，颗粒团块间存在较大空隙，间隙率为61.75%；0.25 ~ 1 mm和0.4 ~ 1 mm组材料颗粒排列较为均匀，颗粒团块间存在间隙较小，间隙率分别为27.33%和42.44%。结论    显微CT可用于颗粒移植材料的微观物理参数评估，0.25 ~ 1 mm组羟磷灰石颗粒压实后颗粒团块内部排列紧密，临床上有利于植骨后稳定成骨空间。

关键词: 显微CT, 骨移植, 颗粒, 间隙, 羟磷灰石