关键词: 上颌窦底提升术, 富血小板纤维蛋白, 牙种植, 骨再生

Abstract: Maxillary sinus floor elevation（SFE） is often used to obtain sufficient bone mass when the bone mass in the posterior maxillary region is insufficient. With the development of the research，it is generally believed that Schneiderian membrane itself has the potential of osteogenesis，the mode of osteogenesis after operation is to maintain a stable space by means of bone graft material，and to form new bone by adhesion，migration and differentiation of mesenchymal stem cells（MSCs）from wound surface and Schneiderian membrane. Conventional bone graft materials lack osteoinductive ability，which leads to low osteogenic efficiency and obvious postoperative response. Therefore，accelerating bone regeneration and reducing the burden of patients are the hot spots of clinical research. Platelet-rich fibrin（PRF）is the second generation of autologous platelet concentrate. As a tissue engineering material，PRF was originally used to repair soft tissue injury，and now it has been widely used in oral implant field. Recent studies have shown that PRF can induce osteogenic differentiation of MSCs. PRF prepared through the standardized process has certain osteoinductive and play a role in angiogenesis. When using in SFE，PRF can regulate various factors in its osteogenic mode and promote new bone formation. PRF membrane can rely on its mechanical strength to maintain the raised sinus floor mucosa. However，there is still a lack of research in the mechanism of PRF promoting bone regeneration. Whether PRF should be routinely applied in SFE is still controversial. This paper mainly reviews the mechanism of PRF promoting bone regeneration after SFE and the clinical application and effect of PRF in different surgical methods，which is aimed to provide reference for clinical decision and further studies.

Key words: maxillary sinus floor elevation, platelet-rich fibrin, dental implantation, bone regeneration