关键词: 外泌体, 肿瘤, 口腔鳞状细胞癌, 肿瘤微环境

Abstract: Exosome is the smallest group of extracellular vesicles and contains abundant information from parental cells. As an important component of tumor microenvironment，exosome can induce pathological processes through intercellular communication and signal transduction. In recent years，it has been found that the exosomes derived from oral and maxillofacial tumor are involved in the occurrence and development of tumors，immune regulation and treatment. Since exosomes are widely present in blood，saliva and other body fluids，detection and analysis of exosomes contents will be helpful for early diagnosis，efficacy evaluation and prognosis judgment of tumors. In this paper，the research progress in the biological function and the clinical application of exosomes in oral and maxillofacial tumors is reviewed in order to provide reference for future researches.

Key words: exosome；tumour；oral squamous cell carcinoma, OSCC；tumor microenvironment