关键词: 瞬时受体电位通道, 牙科疼痛, 局部麻醉, 辣椒素, TRP通道拮抗剂

Abstract: The transient receptor potential（TRP）channel is a group of non-selective cation channels present in primary afferent neurons of the pulp，odontoblasts，and dental pulp fibroblasts. The TRP channel is activated by osmotic pressure，temperature，inflammatory factors，etc.，and generates a potential signal that transmits to central nervous system to cause pain. This nerve conduction mechanism is closely related to the generation of dentin sensitive and pulpitis pain. This paper reviews the recent research progress in TRP channel-mediated dental pain mechanism and regulation of TRP channel in dental pain management. Clinical pain management measures with certain feasibility are put forward，which may become one of the future directions of dental pain research.

Key words: transient receptor potential channel, dental pain, local anesthesia, capsaicin, TRP channel antagonists