关键词: 牙周病, 慢性肾脏病, 关联性, 氧化应激, 炎症因子

Abstract:

Chronic kidney disease（CKD），defined as kidney damage for three or more months associated with structural or functional abnormalities of the kidney，with or without decreased glomerular filtration rate （GFR），is associated with periodontal disease，an infectious oral disease leading to tooth loss. Many epidemiological evidences have recently suggested that CKD is highly prevalent among patients with periodontal disease. Moreover，periodontal disease may also increase the morbidity and severity of CKD and is associated closely with poor prognosis，according to some researches in recent years. However，the detailed mechanism on how periodontal disease debilitate and worsen CKD is yet not clear. Some researchers hypothesize that periodontal disease could exert an influence on CKD via periodontal pathogens，inflammatory mediator and oxidative stress. This review presents certain aspects of possible link between periodontal disease and CKD and provides references for combined clinical treatment.

Key words: periodontal disease, chronic kidney disease, correlation, oxidative stress, inflammatory mediator