中国实用口腔科杂志

中国实用口腔科杂志

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牙周致病菌与动脉粥样硬化相关关系研究进展

徐婉悦，潘亚萍，张冬梅   

  1. 中国医科大学附属口腔医院牙周科，辽宁  沈阳 110002
  • 出版日期:2017-07-15 发布日期:2017-07-25
  • 基金资助:

    国家自然科学基金青年基金（81400518）；辽宁省卫计委省直医院临床诊疗能力建设项目（LNCCC-C08-2015）

  • Online:2017-07-15 Published:2017-07-25

摘要：

牙周病被认为是心血管疾病的独立危险因素，牙周致病菌参与动脉粥样硬化的发生、发展。牙周致病菌通过从口腔环境进入血循环，并侵入血管内皮细胞内生长繁殖，刺激机体释放炎症因子、趋化因子，介导血管内皮细胞与单核细胞相互作用，从而导致血管损伤、动脉粥样硬化形成。

关键词: 牙周病, 牙周致病菌, 动脉粥样硬化, 心血管疾病

Abstract:

Periodontal disease is considered to be one of the independent risk factors of cardiovascular diseases. Mounting evidences have demonstrated that periodontal pathogens may transfer from oral environment into blood circulation and then colonize on vascular cells，where numerous inflammatory cytokines and chemokines will be released and conduct the interactions between vascular endothelial cell and monocyte. Consequently，inflammatory injuries and vessel damages will form，resulting in atherosclerosis，the common characteristic and progression of cardiovascular diseases. This article will review the present research on periodontal pathogens-induced atherosclerosis.

Key words: periodontal disease, periodontal pathogen, atherosclerosis, cardiovascular disease