中国实用口腔科杂志

中国实用口腔科杂志

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中重度牙周炎伴脑卒中高危人群牙周基础治疗效果观察

张燕锋1，孙晓菊2，谢洪2，南顺花3，谢慧心4   

  1. 1. 大连医科大学口腔医学院，辽宁  大连  116000 ；2. 辽宁省人民医院口腔科，辽宁  沈阳  110016；3. 齐齐哈尔医学院附属第三医院，黑龙江  齐齐哈尔  161000；4. 中国医科大学口腔医学院，辽宁  沈阳  110002
  • 出版日期:2016-10-15 发布日期:2016-12-15
  • 基金资助:

    沈阳市科技计划项目（F14-158-9-04）；辽宁省科学事业公益研究基金（2015）

  • Online:2016-10-15 Published:2016-12-15

摘要：

目的    探讨牙周基础治疗对中重度牙周炎伴脑卒中高危人群患者血清中同型半胱氨酸（HCY）炎症因子水平及临床牙周指标的影响。方法    选择2014年1—10月在辽宁省人民医院口腔科及神经内科就诊的中重度牙周炎伴脑卒中高危人群患者76例，随机分为2组：A组40例，接受牙周基础治疗+神经内科治疗；B组36例，仅接受神经内科治疗。另选取单纯中重度牙周炎患者36例，设为C组，接受牙周基础治疗。比较各组治疗前后血清HCY含量及探针出血（BOP）、牙周探诊深度（PD）、附着丧失（AL）等牙周指标的变化。采用SPSS17.0软件包对数据进行统计学分析。结果    与治疗前比较，3组患者血清HCY含量及各项牙周指标均下降。与B组相比，A组血清HCY含量均值较低，但两组差异无统计学意义（P > 0.05）；A组各项牙周指标下降更加明显，两组差异有统计学意义（P < 0.05）。结论    牙周基础治疗可降低中重度牙周炎伴脑卒中高危人群血清HCY水平，改善机体的炎症状态，可在一定程度上降低脑卒中高危人群向脑卒中发展的风险。

关键词: 牙周炎, 脑卒中高危人群, 牙周基础治疗, 牙周指标, 同型半胱氨酸

Abstract:

Objective    To discuss the influence of basic periodontal therapy on the levels of homocysteine（HCY）in serum and clinical periodontal parameters in patients with moderate to severe periodontitis at high risk of stroke. Methods      From January to October 2014，76 cases of patients with moderate to severe periodontitis at high risk of stroke who underwent treatment in Department of Stomatology or Neurology in People's Hospital of Liaoning Province were randomly divided into two groups. Forty cases in group A received basic periodontal treatment and neurology treatment，and 36 patients in group B only received neurology treatment. Another 36 patients with moderate to severe periodontitis were selected as group C，who received basic periodontal treatment. Observe the change of the HCY levels in serum and the clinical periodontal parameters，including bleeding on probing（BOP），probing depth（PD）and attachment loss（AL）. The data were analyzed by SPSS17.0 software package. Results    Compared with pre-treatment，the level of serum HCY and periodontal index of 3 groups decreased. Compared with B group，serum HCY in group A decreased in mean value，and periodontal index decreased more significantly. The difference was statistically significant（P < 0.05）. Conclusion    Basic periodontal treatment can reduce the level of serum HCY in patients with moderate to severe periodontitis at high risk of stroke and improve the body's inflammatory state，which may reduce the risk of high-risk stroke progressing to stroke.

Key words: periodontitis；patients at high risk of stroke；basic periodontal treatment；periodontal parameters；homocysteine, HCY