中国实用口腔科杂志

中国实用口腔科杂志

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冠心病伴慢性牙周炎牙周基础治疗前后血清及龈沟液中IL-8、IL-10检测及其价值研究

李    峰1，孙晓菊1，沈国函2，谢    洪1   

  1. 1. 辽宁省人民医院口腔科，沈阳  110016；2. 大连市口腔医院，辽宁  大连  116021
  • 出版日期:2015-11-15 发布日期:2015-12-16
  • 基金资助:

    辽宁省科学技术计划项目（2013225021）

  • Online:2015-11-15 Published:2015-12-16

摘要：

目的    探讨牙周基础治疗对冠心病伴慢性牙周炎患者血清及龈沟液中白细胞介素（IL）-8、IL-10水平的影响。方法      选取2013年2月至2014年11月在辽宁省人民医院心内科及口腔科就诊患者90例，分为3组：选取冠心病伴慢性牙周炎患者65例，随机分为两组，A组35例行心内科治疗和牙周基础治疗，B组30例仅行心内科治疗；另选无系统性疾病的单纯慢性牙周炎患者25例作为C组，行牙周基础治疗。比较各组治疗前后血清及龈沟液中IL-8、IL-10及各项牙周指标的变化。结果    牙周基础治疗3个月后，A组和C组进行治疗前后自身比较，各项牙周指标均得到有效控制（P < 0.05），血清及龈沟液中的IL-8降低，IL-10升高（P < 0.05）；A组和B组进行治疗前后组间比较，治疗前两组各项指标差异均无统计学意义，治疗3个月后A组各项牙周指标均优于B组，差异有统计学意义（P < 0.05）；A组血清及龈沟液中IL-8较B组明显降低，IL-10较B组明显升高，差异有统计学意义（P < 0.05）。结论    牙周基础治疗不仅能有效改善慢性牙周炎患者牙周局部健康情况，且能降低全身IL-8水平，升高IL-10，控制炎症感染的因素，可能是降低冠心病发生、发展的有效手段之一。

关键词: 牙周炎, 冠心病, 白细胞介素-8, 白细胞介素-10, 牙周基础治疗

Abstract:

Objective    To discuss the influence of basic periodontal therapy on the level of IL-8， IL-10 in serum and gingival crevicular fluid in patients who have chronic periodontitis complicated by coronary heart disease. Methods     A total of 65 cases of patients with chronic periodontitis complicated by coronary heart disease were selected and divided into two groups randomly：Group A of 35 patients who received the basic periodontal therapy and cardiac medical treatment；Group B of 30 patients who received cardiological treatment only. Then，select 25 patient who had developed chronic severe periodontitis with non-systematic disease to establish group C and give them the basic periodontal therapy only. Observe the changes of the IL-8，IL-10 levels in serum and gingival crevicular fluid and the periodontal infection indexes（BI，PD）. Results    The results showed that after three months of basic periodontal therapy the periodontal clinical indices of both group A and group C became better and the IL-8 level obviously reduced，while the IL-10 level obviously increased. There was no obvious difference between group A and group B in each examination index before the therapy. After three months，we found that the periodontal infection index（SBI PD）of group A was obviously better than group B. Compared to group B，the IL-8 level of group A obviously reduced，and the IL-10 level obviously increased. The difference was statistically significant（P < 0.05）. Conclusion    The basic periodontal therapy can effectively improve periodontal conditions of the patients with chronic periodontal diseases，and reduce the risk of breaking the normal cardiovascular function.

Key words: periodontitis, coronary hear disease（CHD）, interleukin-8（IL-8）, interleukin-10（IL-10）, basic periodontal treatment