中国实用口腔科杂志

中国实用口腔科杂志

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寡核苷酸MT01及其在牙周炎方向的研究进展

周    岳，于海蛟，高    涵，刘    引，任春霞    综述，林崇韬    审校   

  1. 吉林大学口腔医学院牙周病科，长春  130021
  • 出版日期:2015-07-15 发布日期:2015-07-22
  • 基金资助:

    国家自然科学基金（81371153）

  • Online:2015-07-15 Published:2015-07-22

摘要：

MT01是依据人线粒体DNA序列设计的单链寡核苷酸，具有免疫负调节活性。多项研究显示，MT01在抑制由病原体感染所引起的有害、过度的免疫反应以及抑制牙槽骨吸收和促进成骨细胞活化方面有着显著的效果。炎症和骨吸收是牙周疾病的本质。本文就MT01的最新研究进展及其在牙周炎方向的相关研究做一综述。

关键词: 寡核苷酸, MT01, 牙周炎, 炎症, 骨吸收

Abstract:

MT01 is a single-stranded oligodeoxynucleotide（ODN）which is designed based on human mitochondrial DNA sequences. It has immune activity of selective negative regulator. Several studies have shown that MT01 has a significant effect in suppressing excessive immune reaction caused by pathogens infection，and it also inhibits the absorption of alveolar bone and promotes osteoblast cell activation. Inflammation and bone resorption are the nature of periodontal diseases. Here we review the latest research progress of MT01 and its related research in periodontitis.

Key words: oligodeoxynucleotide, ODN；MT01；periodontitis；inflammation；bone resorption