关键词: 骨免疫, 成骨细胞, 破骨细胞, 口腔疾病

Abstract: Long-term studies have shown that innate immunity and acquired immunity play a vital role in the process of host's resistance to invasion by foreign microorganisms，and in this process，it will also cause damage to the host's own tissues or organs. Bone system is one of them. In some diseases，such as rheumatoid arthritis and periodontitis，the response of immune system not only plays the role of removing foreign pathogenic bacteria，but causes the destruction of bone system. For a long time，most of the researches have been devoted to understanding the mechanism of the destruction of bone tissue by the immune system. In recent years，some of the researches have begun to explore the reaction of bone to the immune system，which leads to a new research field--osteoimmunology. This review summarizes the research progress in recent years concerning the mechanism of osteoimmunology，functioning pathways of immunization and bone resorption，and the mechanism of action of related diseases in oral cavity.

Key words: osteoimmunology, osteoblast, osteoclast, oral diseases