关键词: COMT基因, 颞下颌关节紊乱病, 精神心理因素, 慢性疼痛

Abstract:

Temporomandibular joint disorders（TMD）are one of the most common and refractory diseases，and significantly influence living quality and physical and psychological health. The risk factors of TMD are more complex，and at present the pathogenesis has not been fully elucidated. In recent years，more people are concerned about the effect of psychological factors，but the effect and mechanism are complex. In foreign literature research of catechol-O-methyltransferase（COMT）as a gene associated with pain shows that before and after stress the COMT gene expression changes in masticatory muscle tissue of patients with TMD，so it can be concluded that there are correlation between the psychological state and COMT gene polymorphism. This article focuses on the effect and adjustment mechanism of COMT gene in TMD.

Key words: COMT gene；temporomandibular joint disorders, TMD；psychological factors；chronic pain