中国实用口腔科杂志

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骨组织工程支架研究进展

徐大朋综述王绪凯审校   

  1. 作者单位:中国医科大学口腔医学院口腔颌面外科,辽宁省口腔医学研究所口腔颌面外科研究室,沈阳110002
  • 出版日期:2014-03-15 发布日期:2014-03-31
  • 通讯作者: 王绪凯
  • 基金资助:

    辽宁省科技计划项目(2012225082)

Research progress of bone tissue engineering scaffolds.

XU Da-pengWANG Xu-kai   

  1. Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Institute of Dental Research, Shenyang 110002, China
  • Online:2014-03-15 Published:2014-03-31

摘要:

组织工程化骨是用于颌骨缺损修复治疗的一种新途径,当前其研究焦点是寻求能够作为细胞移植及引导新骨生长的支架,以充当细胞外基质的替代物。这些支架通常由多孔、可降解的生物材料制备,并且可以负载不同的生长因子、药物或干细胞。本文就骨组织工程支架的研究现状、面临的挑战及未来的研究动向做一综述。

关键词: 骨组织工程, 生物材料支架, 颌骨缺损

Abstract:

Abstract: The tissue-engineered bone is a new approach for jaw defect repair treatment, research focus of which is to seek suitable scaffolds for cell transplantation and guiding the growth of new bone to act as substitutes of the extracellular matrix. These scaffolds are often porous, made of biodegradable materials that harbor different growth factors, drugs or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.

Key words: bone tissue engineering, biomaterial scaffolds, jaw defects

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