中国实用口腔科杂志

中国实用口腔科杂志

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舌癌动物模型研究进展

刘洋，战德松   

  1. 作者单位：中国医科大学口腔医学院口腔材料教研室，辽宁省口腔医学研究所，沈阳110002
  • 出版日期:2013-05-15 发布日期:2013-06-19
  • 通讯作者: 战德松

Animal models of tongue cancer

LIU Yang，ZHAN De-song   

  1. Department of Oral Materiology，School of Stomatology，China Medical University，Liaoning Institute of Dental Research，Shenyang 110002，China
  • Online:2013-05-15 Published:2013-06-19

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摘要：

舌癌是口腔癌中发病率最高的恶性肿瘤，早期特异性生物学标志物的缺乏、肿瘤转移和复发导致了舌癌患者的5年生存率几十年来都停滞在50％左右的较低水平。动物模型在人类疾病的研究中起着十分重要的作用，建立舌癌动物模型将推动舌癌发病机制和防治措施的研究进展。本文将对舌癌动物模型的建立方法、原理和主要应用领域进行综述，并对各种建模方法的优缺点进行分析和评价。

关键词: 舌癌, 动物模型, 化学诱发模型, 移植瘤模型, 遗传工程

Abstract:

Abstract：Tongue cancer is the most common malignancy of oral cancer，and its 5-year survival rate has been stagnated in 50％ for decades due to lack of early specific biomarkers，metastasis or recurrence. Animal models play an important role in studying human disease，and research in mechanism of tongue carcinogenesis and prevention may be promoted by animal models of tongue cancer. This article summarized the methods，principle and major application fields of several animal models of tongue cancer，then their relative merits analyzed.

Key words: tongue cancer, animal models, chemical induced model, implanted tumor model, genetic engineering

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