关键词: D-氨基酸, 细菌生物膜, 分散作用, 牙菌斑, 抗生素

Abstract: Bacteria are the main causes of infectious diseases. Bacterial secretions including extracellular polysaccharides gather together to form a dense biofilm，making it difficult for antibiotics to exert bactericidal effects and even producing drug resistance. The presence of bacterial biofilms makes clinical treatment difficult. Oral dental plaque biofilm is the initiating factor for the occurrence and development of dental caries. Therefore，effective removal and control of dental plaque biofilm is the key to preventing and treating dental caries. Studies have shown that D-amino acid，as a biofilm signal molecule，can promote the dispersion of biofilm，which promotes the antibacterial effect of antibacterial drugs. This article will review the research progress in the dispersion effect of D-amino acids on bacterial biofilms，and provide new ideas for making clinical treatment schemes to remove oral plaque biofilms.

Key words: D-amino acid, bacterial biofilms, dispersion, dental plaque biofilm, antibiotics