中国实用口腔科杂志

中国实用口腔科杂志

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顽固性与普通性复发性阿弗他溃疡的人口社会学资料对比研究

刘芹1，段宁1，王翔1，阮欢欢2，宋月凤1，林琳1，蒋红柳1，黎景景1，王文梅1   

  1. 1.南京大学医学院附属口腔医院，南京市口腔医院口腔黏膜病科，江苏  南京  210008；2.合肥市口腔医院牙周黏膜科，安徽  合肥  230000
  • 出版日期:2019-09-15 发布日期:2019-10-25
  • 基金资助:

    国家自然科学基金 （81570978，81870767）；江苏省临床医学科技专项（BL2014018）；江苏省医学青年人才项目（QNRC2016118）；南京市卫生科技发展专项资金项目计划（ZKX17033，YKK18127）

  • Online:2019-09-15 Published:2019-10-25

摘要：

目的　比较并分析顽固性与普通性复发性阿弗他溃疡（RAU）的人口社会学资料特征，为顽固性RAU的病因及防治提供参考依据。方法　选取2014年7月至2018年6月于南京大学医学院附属口腔医院口腔黏膜病科就诊的顽固性RAU患者339例（顽固性RAU组）、普通性RAU患者301例（普通性RAU组），另选取同期来本院进行健康体检的230名健康成人为对照组。统计各组研究对象的人口社会学资料及临床特征，应用SPSS18.0统计软件进行统计分析。结果　顽固性RAU组和普通性RAU组研究对象中有RAU家族史的比例、戒烟的比例均高于对照组（P＜0.05），且顽固性RAU组研究对象戒烟的比例高于普通性RAU组（P＜0.05）；顽固性RAU组研究对象中有压力的比例高于普通性RAU组和对照组（P＜0.05），与月经周期相关、饮酒史的比例低于普通性RAU组（P＜0.05）；顽固性RAU组和普通性RAU组研究对象中有吸烟史的比例均低于对照组（P＜0.05）；顽固性RAU组、普通性RAU组和对照组研究对象在性别、消化系统疾病患者占比、糖尿病患者占比、食物药物过敏史、文化程度方面差异均无统计学意义（P＞0.05）。结论　RAU与遗传、月经周期、吸烟史、戒烟、饮酒史、压力等因素相关，其中顽固性RAU较普通性RAU与压力及戒烟因素关系更为密切。

关键词: 复发性阿弗他溃疡, 顽固性, 普通性, 人口社会学, 发病因素

Abstract:

Objective  The demographic sociological characteristics of refractory and general recurrent aphthous ulcer（RAU） were compared and analyzed to provide reference for the etiology，prevention and treatment of refractory RAU.  Methods　A total of 339 patients with refractory RAU（refractory RAU group） and 301 patients with general RAU（general RAU group） were treated in the  Department of Oral Membrane Disease，Medical School of Nanjing University from July 2014 to June 2018. In addition， 230 healthy adults who came to the hospital for health checkup in the same period were selected as the control group. The sociological data and clinical characteristics of the population of each group were collected， and statistical analysis was performed using SPSS18.0 statistical software. Results　The proportion of family history and smoking cessation in the refractory RAU and the general RAU was higher than that in the control（P＜0.05）. In addition，the proportion of smoking cessation in the refractory RAU group was higher than that in the general RAU group（P＜0.05）. The proportion of patients with stress in the refractory RAU group was significantly higher than that in the general RAU group and the control group（P＜0.05）. The proportion associated with the menstrual cycle and that of drinking history in the refractory RAU were lower than that in the general RAU（P＜0.05）. The proportion of people with smoking history in the refractory RAU and the general RAU was lower than that in the control（P＜0.05）. There was no significant difference among the three groups in gender，the proportion of patients with digestive system diseases，the proportion of patients with diabetes，the history of food and drug allergy，or the level of education（P＞0.05）. Conclusion　The results of this study show that recurrent aphthous ulcer is associated with genetic，menstrual cycle，smoking history，smoking cessation，drinking history，stress and other factors，and refractory RAU is more closely related to smoking cessation and stress than general RAU.

Key words: recurrent aphthous ulcer, refractory, general, demographic sociology, etiology