中国实用儿科杂志

中国实用儿科杂志

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儿童风湿病国际相关诊治指南系列解读之一——EULAR-ACR系统性红斑狼疮分类标准解读

  

  1. 中国医学科学院 北京协和医学院 北京协和医院儿科，北京 100005
  • 出版日期:2020-04-06 发布日期:2020-04-20

Interpretation of international guidelines for diagnosis and treatment of rheumatism in children（Ⅰ）：Interpretation of the EULAR/ACR classification criteria of systemic lupus erythematosus

  1. Department of Pediatrics，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China
  • Online:2020-04-06 Published:2020-04-20

摘要： 系统性红斑狼疮（SLE）是一种以多系统损害和血清中出现自身抗体为特征的自身免疫性疾病。20多年来，其分类标准经历了不同专业协会或团体的几轮修改，每个标准具有不同的敏感性和特异性，为了更好地提高临床诊断的特异性和敏感性，欧洲抗风湿病联盟（European League Against Rheumatism，EULAR）联合美国风湿病学会（ACR）于2019年发布了新的SLE分类系统。文章将结合笔者的理解简要介绍该标准的应用。

关键词: 系统性红斑狼疮, 儿童发病, 分类标准

Abstract: Systemic lupus erythematosus（SLE） is a complex autoimmune disease characterized by multisystemic damages and the presence of autoantibodies. In the past twenty years，the classification criteria for SLE?had been revised and updated by different professional associations or specialized groups，in each of which the sensitivity and specificity varied. With a goal of improving the specificity and sensitivity of clinical diagnosis，the European League Against Rheumatism（EULAR） and the American College of Rheumatology（ACR） jointly published a new set of classification criteria in 2019. This?paper will briefly introduce and describe the application of the newest classification criteria based on my own understanding of it.

Key words: systemic lupus erythematosus（SLE）, childhood-onset, classification criteria