中国实用儿科杂志

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原发性免疫缺陷患儿呼吸道合胞病毒感染情况分析

刘平赵晓东   

  1. 作者单位:重庆医科大学附属儿童医院P2实验室 重庆,400014(第一作者现工作于郑州市儿童医院肾脏风湿科 河南 郑州,450000)
  • 出版日期:2014-12-06 发布日期:2014-12-08

Respiratory syncytial virus infection in children with primary immunodeficiency.

LIU PingZHAO Xiao-dong.   

  1. Laboratory Biosafety-2,Institute of Pediatrics,Children's Hospital of Chongqing Medical University,Chongqing 400014,China
  • Online:2014-12-06 Published:2014-12-08

摘要:

目的 了解原发性免疫缺陷(primary immunodeficiency,PID)患儿呼吸道合胞病毒(RSV)感染情况及临床特征。方法 收集2009年4月至2010年9月于重庆医科大学附属儿童医院就诊的PID患儿鼻咽吸取物30份,采用荧光定量PCR( real-time RT-PCR )方法检测RSV,对阳性标本进行病毒分离;并收集临床资料,分析其临床特征。结果 30份标本中检测出11份RSV,阳性率为36.7%。其中无感染症状2例(18.2%),支气管炎3例(27.3%),肺炎6例(54.5%)。2例无症状患儿近期均静脉滴注丙种球蛋白(IVIG)。结论 PID患儿更易感染RSV;IVIG应用于免疫缺陷患儿能够降低RSV肺炎的发生率。

关键词: 原发性免疫缺陷, 呼吸道合胞病毒, 荧光定量PCR

Abstract:

Abstract: Objective In this study, we describe the clinical characteristics associated with respiratory syncytial virus(RSV) infection in children with primary immunodeficiency(PID). Method Thirty specimens were collected from children with PID from Apr. 2009 to Sep. 2010 and analyzed for the presence of RSV using real-time chain reaction assay.To further verify the presence of the virus,viral isolation was used to ensure reproducibility. Results The presence of RSV was detected respectively in 11 (36.7%) of the 30 children studied, including symptomless patient 2 cases(18.2%),bronchitis 3 cases (27.3%)and pneumonia 6 cases(54.5%).Two symptomless patient with RSV infection were treated with intravenous immune globulin (IVIG). Conclusion PID children are at increased risk of RSV infection; IVIG can reduce the incidence of RSV pneumonia.

Key words: primary immunodeficiency, respiratory syncytial virus, fluorescence quantitative PCR

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