中国实用儿科杂志

中国实用儿科杂志

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慢性腹泻与原发性免疫缺陷病

  

  1. 深圳市儿童医院风湿免疫科，广东  深圳  518038
  • 出版日期:2021-07-06 发布日期:2021-08-31

Chronic diarrhea and primary immunodeficiency

  1. Department of Rheumatology and Immunology，Shenzhen Children’s Hospital，Shenzhen  518038，China
  • Online:2021-07-06 Published:2021-08-31

摘要： 慢性腹泻是儿科常见的胃肠道症状，而胃肠道是人体最大的免疫器官，储存淋巴细胞最多。多种原发性免疫缺陷病将出现胃肠道表现，包括顽固性腹泻、吸收不良、炎症性肠病/类炎症性肠病或生长迟滞等。文章将阐述原发性免疫缺陷病相关慢性腹泻的病因、线索提示、临床特征及处理措施。

关键词: 慢性腹泻, 原发性免疫缺陷病, 联合免疫缺陷病, 慢性肉芽肿, 湿疹血小板减少伴免疫缺陷综合征

Abstract: Chronic diarrhea is a common gastrointestinal symptom in pediatrics. The gastrointestinal tract is the biggest organ of the immune system，with the largest reservoir of lymphocytes in the human body. A variety of primary immunodeficiency diseases present with gastrointestinal manifestations，including refractory diarrhea，malabsorption，inflammatory bowel disease（IBD）/IBD-like，or failure to thrive. This article will describe the etiology，clinical clues，clinical features and management of chronic diarrhea associated with primary immunodeficiency disease.

Key words: chronic diarrhea, primary immunodeficiency, combined immunodeficiency, chronic granulomatous disease, Wiskott-Aldrich syndrome