中国实用儿科杂志 ›› 2011, Vol. 26 ›› Issue (10): 760-.

• 论著 • 上一篇    下一篇

孤独症患儿头围测量分析

  

  1. 中国医科大学附属盛京医院发育儿科,沈阳 110004
  • 出版日期:2011-10-06 发布日期:2011-10-13
  • 基金资助:

    基金项目:国家自然科学基金资助项目(30872802);辽宁省教育厅课题(2008816)

Head circumference measurements in children with autism.

  1. Developmental Pediatrics of Shengjing Hospital,China Medical University,Shenyang 110004,China
  • Online:2011-10-06 Published:2011-10-13

摘要:

摘要:目的 探讨孤独症患儿头围发育情况。方法 研究对象为中国医科大学附属盛京医院2009年9月至2011年6月确诊的孤独症患儿(孤独症组)156例,其中≤3岁74例, > 3岁82例。同时选择健康儿童141名作为正常对照组,其中≤3岁58名, > 3岁83名。分别测量两组头围并进行组间比较。结果 孤独症组≤3岁患儿头围平均值与大头所占比例均大于正常对照组,两组差异有统计学意义(P < 0.05)。孤独症组 > 3岁患儿头围平均值与大头所占比例与健康儿童基本相似,两组差异无统计学意义(P > 0.05)。在除外大头患儿后,两组头围平均值比较差异无统计学意义(P > 0.05)。结论 孤独症患儿生后早期头围偏大,并且常伴大头,头围异常也是患儿重要的临床特征之一。了解孤独症头围发育可为孤独症的发病机制提供参考依据。

关键词: 孤独症, 头围, 大头

Abstract:

Abstract:Objective To assess the head circumference in children with autism. Methods One hundred and fifty-six children with autism (74 children ≤ 3 years and 82 children  > 3 years, respectively) and 141 well-matched healthy controls(58 children ≤3 years and 83 children > 3 years, respectively) were investigated by measuring the head circumference. Results The autistic children demonstrated significantlyhigher head circumference than the control children in the ≤3 years group (P < 0.05).Compared to the healthy controls, the autistic individuals also manifested more macrocephalus(P < 0.05). However, when the children who displayed macrocephalus were excluded, there was no significant difference in the head circumference between the two groups. Conclusion Head circumference abnormalities are a common feature of autistic patients and may provide some clues to the pathogenesis of autism.

Key words: autism, head circumference, macrocephalus