关键词: 异种移植, 器官移植, 基因编辑技术, 凝血功能障碍, 感染

Abstract: With the increase in life expectancy of human beings, the number of patients with chronic diseases and end-stage organ failure is growing. Organ transplantation, which is considered as an effective treatment, is limited by the severe shortage of donor organs. In this context, xenotransplantation emerges as a promising alternative therapy, showing great potential to meet the pressing demand of donor organs, tissues and cells. Owing to the development of the relevant theories and technologies such as gene editing, immunosuppression and organ preservation, the feasibility of clinical xenotransplantation is increasing. Nevertheless, the clinical application of xenotransplantation is still in the preliminary stage of exploration. 

Key words: xenotransplantation, organ transplantation, gene editing technology, coagulation disorders, infection