关键词: 甲状腺未分化癌, 美国甲状腺学会, 分子检测, 靶向治疗

Abstract: Interpretations on the updates of the 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer        JI Xiao-yu，SUN Wei，ZHANG Hao. Department of Thyroid Surgery，the First Hospital of China Medical University，Shenyang 110001，China
Corresponding author: ZHANG Hao，E-mail：haozhang@cmu.edu.cn
Abstract    Anaplastic Thyroid Cancer（ATC） is rare in clinical practice，the prognosis is poor. In 2012，the American Thyroid Association formulated the first edition of the guidelines for management of patients with ATC to guide clinicians and researchers to conduct standardized diagnosis and treatment management. As a result of molecular testing and targeted therapy accumulate，the American Thyroid Association updated the guidelines in 2021. The new version of the guidelines emphasizes the role of BRAFV600E molecular detection in diagnosis and targeted therapy，and increases the content of targeted therapy. Targeted therapy is more recommended for patients with advanced unresectable ATC，while chemotherapy is more used for bridging therapy and final treatment. In addition，the humanistic care of patients is also enriched and improved in the new guidelines.

Key words: anaplastic thyroid cancer, American Thyroid Association, molecular detection, targeted therapy