关键词: 肝细胞癌, 复发, 转移, 分子标记物, 分子机制

Abstract:

Progress in the molecular mechanism and the prediction of postoperative recurrence of hepatocellular carcinoma            YANG Xin，JIA Hu-liang，QIN Lun-xiu. Department of General Surgery，Huashan Hospital，Fudan University，Shanghai 200040，China
Corresponding author：QIN Lun-xiu，E-mail：qinlx@fudan.edu.cn
Abstract    The radical resection is the most important treatment for primary liver cancer, but the high recurrence rate is the main obstacle to the survival of postoperative patients. According to the time of tumor recurrence, the postoperative recurrence of liver cancer is divided into the early recurrence and late recurrence. The former is mainly related to the invasion and metastasis of liver cancer, and the latter is mainly caused by multicenter tumor occurrence based on the background of liver disease. The early prediction of postoperative recurrence risk contributes to the timely and effective intervention and improved the prognosis of the patients. In the past ten years, the clinical research on the recurrence of liver cancer has been systematically studied. The molecular mechanism of the metastasis and recurrence has been newly recognized: the metastatic potential of liver cancer begins in the early stage of primary tumor; the imbalance of micro-environmental inflammatory response promotes the metastasis of cancer. At the same time, a variety of molecular markers for predicting the recurrence of liver cancer were identified, and a molecular prediction model for the metastasis of liver cancer was created and optimized. These research results lay the foundation for more accurately understanding of the recurrence and metastasis of liver cancer and developing the more precise prevention and treatment strategies.

Key words: hepatocellular carcinoma, recurrence, metastasis, molecular markers, molecular mechanism