关键词: 直肠癌, 复发, 预后

Abstract:

Analysis of clinicopathological features and prognosis in 47 patients with presacral recurrent rectal cancer                  GUO Peng, WANG Chang, XIE Qi-wei, et al. Department of GI surgery, People’s Hospital, Peking University, Beijing 100010, China
Correspongding authors:WANG Shan，E-mail: shwang60@sina.com;YE Ying-jiang，E-mail: yeyingjiang@pkuph.edu.cn
GUO Peng and WANG Chang are the first authors who contributed equally to the article
Abstract    Objective    To investigate the clinicopathological features and prognosis in patients with presacral recurrent rectal cancer. Methods    Clinical data of 47 patients with presacral recurrent cancer in Peking University People’s Hospital from January 2008 to December 2015 were retrospectively reviewed. The  clinicopathological and follow up data of these 47 patients were analyzed retrospectively, and Cox proportional hazard model was used to analyze the prognostic factors of presacral recurrent rectal cancer. Results    Among above 47 patients, 30 were male and 17 were female, with a male-to-female ratio of 1.8:1.0, followed up for 18(2-72)months. The median recurrent age was 59(range: 34 to 83) years and the median recurrent gap time was 2 years. The main symptom in 44.7%(21/47) patients was pain. The overall median survival time was 25(range: 1 to 65) months. Univariate analysis showed that primary tumor stage, treatment methodand R0 resection influenced prognosis. The result of multivariate analysis demonstrated that R0 resection, primary tumor stage Ⅰ/Ⅱ, primary therapy without adjunctive therapy were independent good prognostic factors. Conclusion    Patients tend to diagnosis presacral recurrent rectal cancer within 2 years after primary surgery. The main symptom is pain. Patients performed R0 resection have a relative good prognosis.

Key words: rectal cancer, recurrence, prognosis