关键词: 肝癌, 免疫治疗, 肿瘤疫苗, 细胞因子活化细胞, 免疫检测点

Abstract:

Recent progress of biological immunotherapy for hepatocellular carcinoma        ZHU Ying，QIN Lun-xiu. Department of General Surgery，Huashan Hospital，Cancer Metastasis Institute，Fudan University，Shanghai 200040，China
Corresponding author：QIN Lun-xiu，E-mail：qinlx@fudan.edu.cn
Abstract    Biological immunotherapy is regarded as the most hopeful therapeutic strategy for hepatocellular carcinoma (HCC)，particularly in combating metastatic recurrence after surgical treatments. The liver microenvironment of HCC patients is characterized by a strong immune suppressive activity. Counterbalancing such as immune-suppressive environment with immune stimulatory approaches including cancer vaccines，cytokines and autologous cytokine-induced killer cells，immune-checkpoint blocking antibodies and macrophages is helpful to control HCC. Many clinical trials have demonstrated that interferon and adjuvant cytokine-induced killer cells are useful for decreasing postoperative tumor relapse and prolonging overall survival. In recent years，PD1/PD-L1 inhibitors and chimeric antigen receptor (CAR)-T cells have brought new hopes in the treatment of HCC. It is worth paying attention to the combined application, individualized precision customization, hepatic cancer specific antigen recognition.

Key words: hepatocellular carcinoma, immunotherapy, cancer vaccines, cytokine-induced killer cells, immune checkpoint blockers