中国实用外科杂志

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胃肠间质瘤预后相关因素

张    波   

  1. 四川大学华西医院胃肠外科,四川成都610041
  • 出版日期:2015-04-01 发布日期:2015-03-31

  • Online:2015-04-01 Published:2015-03-31

摘要:

胃肠间质瘤(GIST)是一组起源于胃肠道间叶源性的肿瘤,其发病率低,恶性程度有时难以评估。即使完整切除GIST后,部分病人术后仍容易发生肿瘤复发或远处转移,准确的评估GIST恶性程度及预后影响因素对指导临床个体化治疗有着重要的意义。近年来,随着临床医师对其认识的不断加深,根据其预后因素制定了多种复发危险度分级标准以判断GIST预后的评估模型。GIST预后的影响因素有肿瘤部位、大小、核分裂像数、肿瘤是否破裂、基因突变类型以及肿瘤免疫组化标记物等。

关键词: 胃肠间质瘤, 预后

Abstract:

Factors related to prognosis of gastrointestinal stromal tumor        ZHANG Bo. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
Abstract    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in the gastrointestinal tract, which is with a low incidence and difficult to estimate the level of malignancy sometimes. However, some patients experienced tumor recurrence or metastasis postoperatively, even though complete resection was obtained. Accurate assessment of the malignant degree of GIST has a very important clinical significance to evaluate its prognosis and establish individualized treatment strategy. More recently, the further understanding of GIST leads to develop various types of criterion to estimate risk of postoperative recurrence. Prognostic factors of GIST include tumor location, size, mitotic index, rupture of tumor, gene mutation status and tumor immunohistochemical markers, etc.

Key words: gastrointestinal stromal tumor, prognosis