关键词: 胃肠间质瘤, 伊马替尼, 靶向治疗

Abstract:

Strategy and evaluation of diagnosis and treatment on recurrent gastrointestinal stromal tumor        LIU Tong, ZHAO Zhi-cheng. Department of General Surgery, Tianjin Medical University General Hospital and Tianjin Institute of General Surgery，Tianjin 300052, China
Corresponding author: LIU Tong, E-mail: liutonga@126.com
Abstract    The recurrence following complete resection of primary gastrointestinal stromal tumor (GIST) is a common clinical problem, including three types which are local recurrence in situ, peritoneal dissemination and distant organ metastases. As targeted therapy, the availability of imatinib has altered the treatment approach and improved the outcome of recurrent GIST.  Accurate assessment of recurrent lesions using imaging modalities, careful understanding of patient’s medication administrating and general physical condition could be helpful for the choice of therapeutic strategy scientifically. Imatinib is the first line treatment for recurrent GIST and should be administrated continually until patient intolerant or disease progresses because of rare pathologic complete respond. Combined with targeted therapy, appropriate surgical intervention to resection of recurrent or metastatic focus can bring a survival benefit to the patients.

Key words: gastrointestinal stromal tumor, imatinib, targeted therapy