中国实用外科杂志

中国实用外科杂志 ›› 2011, Vol. 31 ›› Issue (04): 308-310.

• 论著 • 上一篇    下一篇

伊马替尼治疗胃肠间质瘤疗效评估标准研究

王春萌a，师英强a，吴江宏a，朱蕙燕a，成宇帆b   

  1. 复旦大学附属肿瘤医院  a.胃及软组织外科b.病理科，上海200032
  • 出版日期:2011-04-01 发布日期:2011-05-30

  • Online:2011-04-01 Published:2011-05-30

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摘要：

目的    探讨胃肠间质瘤（GIST）靶向治疗评估新标准。方法    分析2004年8月至2010年10月复旦大学附属肿瘤医院行伊马替尼治疗GIST获得完全缓解的4例病人的临床资料，比较术后病理与术前影像学的差异。结果    4例病人中，2例为影像学评估，其中1例同时接受CT和PET-CT评估；另外2例同时接受影像学和病理学评估，两者评估结果完全不同。结论    在GIST病人伊马替尼疗效评估中，Choi标准有可能取代RECIST标准，成为新的评估标准。

关键词: 胃肠间质瘤, 伊马替尼, Choi 标准, RECIST标准

Abstract:

Analysis on the evaluation criteria for therapeutic effect of imatinib in GIST        WANG Chun-meng*, SHI Ying-qiang, WU Jiang-hong, et al. *Department of Gastric and Soft Tissue Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Corresponding author: SHI Ying-qiang, E-mail: yingqingshi@126.com
Abstract    Objective    To explore a new evaluation on target therapy in GIST patients. Methods    The clinical data of 4 cases of GIST obtained complete remission after using imatinib between August 2004 and October 2010 at Fudan University Shanghai Cancer Center was analyzed. The imaging by CT or PET-CT scan before operation and pathology results after resection of 4 cases were compared. Results In 4 cases of GIST, 2 cases were evaluated only by imaging ( case 1 was evaluated by both CT and PET-CT), and another 2 cases were evaluated by both imaging and pathology. CT scans of cases performed resection after imatinib therapy was in contradiction of the findings of histopathological examination. Conclusion    The Choi response criteria are superior to the RECIST criteria, and may become the mainstay in the evaluation of imatinib response in GIST cases. 

Key words: GIST, imatinib, Choi criteria, RECIST criteria