中国实用外科杂志

中国实用外科杂志 ›› 2006, Vol. 26 ›› Issue (02): 1-114.

• 论著 •    

生长抑素对肝癌术后血浆内血管内皮生长因子和转化生长因子-B1水平影响的研究

梁蔚文，龚时文，傅玉如，范新兰   

  1. 中山大学附属第二医院医学研究中心，广东广州 510120
  • 收稿日期:2005-10-09 修回日期:2005-11-10 出版日期:2006-01-23 发布日期:2006-01-23

The effect of somatostatin on the levels of plasma vascular endothelial growth factor and transforming growth factor beta1 after hepatectomy in hepatocellular carcinoma patients.

Liang Weiwen,Gong Shiwen,Fu Yuru,et al.   

  1. Research Center of Medicine,the Second Affiliated Hospital,Sun YatSen University,Guangzhou 510120,China
  • Received:2005-10-09 Revised:2005-11-10 Online:2006-01-23 Published:2006-01-23

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摘要：

目的:研究肝癌肝切除后血浆血管内皮生长因子（VEGF）和转化生长因子-β1 （TGF-β1）的变化，与生长抑素（SST）对肝切除后血浆VEGF和TGF-β1变化的影响。方法:将2002～2003年拟行手术治疗的20例肝癌病人随机分为治疗组与对照组，每组各10例，用双抗体夹心ELISA方法检测病人手术前后血浆VEGF和TGF-β1的浓度变化。结果:对照组术后血浆VEGF与TGF-β1 浓度较术前明显增高（P<0.05）。SST治疗组术后血浆VEGF与TGF-β1浓度较对照组术后明显降低（P<0.05）。结论:应用SST能明显降低血浆VEGF与TGF-β1的浓度，VEGF与TGF-β1促残瘤生长的作用可能受到抑制，提示SST对于预防肝癌手术后残瘤的复发可能有作用。

关键词: 生长抑素；血管内皮生长因子；转化生长因子-&beta, 1 ；肝癌

Abstract:

Objective:To investigate the effect of somatostatin (SST) on the levels of plasma vascular endothelial growth factor (VEGF) and transforming growth factor beta1 (TGF-β1) after hepatectomy in hepatocellular carcinoma patients. Methods:From March 2002 to April 2003,20 patients after hepatectomy were randomly divided into two groups,SST treatment group (10 cases) and control group (10 cases).The plasma levels of VEGF and TGFβ1 were measured by Elisa method. Results:The plasma levels of VEGF and TGF-β1 after hepatectomy in control group were significantly increased than that before operation,P<0.05.The plasma levels of VEGF and TGF-β1 after hepatectomy in SST treatment group was significantly decreased than that in control group，P<0.05. Conclusion:The administration of SST after hepatectomy could significantly decreased the plasma levels of VEGF and TGFβ1.The effect of enhancing growth of residual tumor tissue by VEGF and TGFβ1 might be suppressed.The result showed that the administration of SST might be beneficial to prevent the recurrence of residual tumor after surgery.

Key words: Somatostatin；Vascular endothelial growth factor；Ransforming growth factor-&beta, 1；Liver cancer